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NEUPRO® (rotigotine transdermal system) is a prescription medicine used to treat Parkinson’s disease.

Applying the NEUPRO Patch

Making sure it’s ON—and that it stays on

It's important to apply the NEUPRO® (rotigotine transdermal system) Patch correctly so you get the dose of medicine your doctor prescribed. Take a few minutes to watch the video and read through the instructions on how to apply the NEUPRO Patch.

Read the Instructions for Use that comes with your NEUPRO Patch before you start using it and each time you get a refill. There may be new information. This printout does not take the place of talking to your doctor about your medical condition or treatment.


Take a few minutes to watch this video on how to apply the NEUPRO Patch


  • Do not use NEUPRO if you are allergic to rotigotine or any of the other ingredients in the patch.
  • Use NEUPRO exactly as your doctor tells you to use it.
  • NEUPRO comes in 4 different size (dose) patches for Parkinson's disease. Your doctor should start you on a low dose of NEUPRO. Your doctor will change the dose weekly until you are taking the right amount of medicine to control your symptoms. It may take several weeks before you reach the dose that controls your symptoms best.
  • Apply NEUPRO 1 time each day at the same time each day.
  • You may bathe, shower, or swim while wearing a NEUPRO Patch. Water may loosen your NEUPRO Patch.
  • If the edges of the patch lift, you may tape them down with bandaging tape.
  • If your NEUPRO Patch falls off, apply a new NEUPRO Patch for the rest of the day. The next day, apply a new patch at your regular time.
  • If you miss a dose or forget to change your NEUPRO Patch, apply a new NEUPRO Patch as soon as you remember. Replace the NEUPRO Patch at your normal time the next day.
  • Talk to your doctor often about your condition. Do not stop or change your treatment with NEUPRO without talking to your doctor.
  • Read the Instructions for Use and watch the video above for specific information about the right way to apply the NEUPRO Patch.

What to avoid

  • Do not drive, operate machinery, or do other dangerous activities until you know how NEUPRO affects you.
  • Avoid exposing the site where you have applied your NEUPRO Patch to heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds, and direct sunlight. Too much medicine could be absorbed into your body.
  • Do not use NEUPRO during certain medical procedures called magnetic resonance imaging (MRI) or cardioversion. Using NEUPRO during these procedures could cause a burn to the site where you applied your NEUPRO Patch.
  • Avoid direct sunlight if you get a skin rash or irritation from NEUPRO until your skin heals. Sun exposure could lead to skin color changes.


NEUPRO is a prescription medicine used to treat Parkinson's disease.

Important Safety Information

NEUPRO contains a sulfite called sodium metabisulfite. Sulfites can cause severe allergic reactions that are life threatening to some people who are sensitive to sulfites. People with asthma are more sensitive to sulfites. Remove the patch right away and call your doctor if you have swelling of the lips or tongue, chest pain, or trouble breathing or swallowing.

NEUPRO may make you fall asleep suddenly or without warning while doing normal activities, such as driving, which may result in accidents. Tell your doctor right away if this happens. Drinking alcohol or taking other medicines that cause drowsiness may increase your chances of becoming sleepy while using NEUPRO. Do not drive, use hazardous machinery, or do other dangerous activities until you know how NEUPRO affects you.

NEUPRO can cause or worsen psychotic symptoms including hallucinations (seeing or hearing things that are not real), confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs (believing things that are not real), and disorganized thinking. The chances of having hallucinations or these other psychotic-like changes are higher in people with Parkinson's disease who are elderly, taking NEUPRO, or taking higher doses of NEUPRO. If you have any of these problems, talk to your doctor.

NEUPRO can cause decreases in blood pressure, especially when you start or increase your dose. Increases in blood pressure and heart rate, fainting, weight gain, and fluid retention also can occur. If you faint or feel dizzy, nauseated, or sweaty when you stand up from sitting or lying down, or have an unusually fast increase in weight, swelling, or fluid retention, especially in the ankles or legs, tell your doctor.

Some patients using NEUPRO get urges to behave in a way that is unusual for them, such as unusual urges to gamble, strong urges to spend money, binge eating, or increased sexual urges and behaviors. If you or your family notices you are developing any unusual behaviors, talk to your doctor.

NEUPRO may cause uncontrolled, sudden movements or make such movements you already have worse or more frequent if you have Parkinson's disease, which may mean that your antiParkinson's medicine needs to be changed.

Skin reactions may occur at the site where you apply NEUPRO. Tell your doctor if you get a rash, redness, swelling, or itching that will not go away.

Avoid exposing the NEUPRO patch you are wearing to heating pads, electric blankets, heat lamps, saunas, hot tubs, heated water beds, and direct sunlight. Too much medicine could be absorbed into your body. Also, do not wear NEUPRO during medical procedures called magnetic resonance imaging (MRI) or cardioversion because this could cause skin burns.

Tell your doctor if you have breathing problems, a sleep disorder, mental problems, high or low blood pressure, or heart problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. NEUPRO may not be right for you.

The most common side effects in people taking NEUPRO for Parkinson's disease are nausea, vomiting, sleepiness, application site reactions, dizziness, loss of appetite, difficulty falling asleep and staying asleep, increased sweating, vision problems, leg swelling, and uncontrolled, sudden movements of the arms or legs.

These are not all the possible side effects of NEUPRO. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088. You may also report side effects to UCB, Inc. at ucbCARES® (1-844-599-2273).

Please see additional Patient Information about the NEUPRO Patch. This information does not take the place of talking with your healthcare provider about your condition or your treatment.


We recognize that coronavirus may be top of mind. Our focus, as always, is the health and safety of our patients. Now, more than ever, we recommend speaking with your specialist on specific questions you may have regarding treatment and overall health. You can also contact our ucbCARES® team for product-specific questions directly at 1-844-599-2273. Hours of operation continue as Monday-Thursday, 8 AM-8 PM ET and Friday, 8 AM-5 PM ET.